Intracellular monoatomic anion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular monoatomic anion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LENG1, IL17C, and OPA3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular monoatomic anion homeostasis activity versus LENG1 in CNS (Pearson r = 0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LENG1 →	+0.619	+0.423	<.001	.002	2	2
CNS	IL17C →	+0.110	+0.423	<.001	.002	2	2
CNS	OPA3 →	+0.544	+0.423	.009	.002	2	2
CNS	GNG13 →	+0.540	+0.423	.004	.002	2	2
CNS	GPM6A →	+5.241	+0.423	.004	.002	2	2
CNS	LIPC →	+0.163	+0.423	<.001	.002	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030002 vs LENG1 — CNS

Explore this scatter interactively →