Neuronal signal transduction

Across TCGA patient cohorts, RNA activity of the Neuronal signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C17orf75, SH3GLB1, and ADAMTSL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal signal transduction activity versus C17orf75 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C17orf75 →	+0.304	+0.065	<.001	<.001	3	5
GBM	SH3GLB1 →	-0.229	-0.064	.007	<.001	2	5
COAD	ADAMTSL1 →	-1.167	-0.061	.005	.001	3	4
LSCC	CAPZB →	-0.164	-0.061	<.001	<.001	3	4
OV	AFAP1_S668 →	-1.215	-0.077	<.001	<.001	3	4
PDAC	GATM →	+0.421	+0.046	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023041 vs C17orf75 — LSCC

Explore this scatter interactively →