Neuronal signal transduction

Across TCGA pan-cancer cohorts, RNA activity of the Neuronal signal transduction pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Neuronal signal transduction pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and LUAD, show the opposite pattern, with higher activity associated with better survival.

BLCA, LUAD, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.515	0.352	<.001	126	view →
LUAD	OS	Median	All	0.748	0.623	<.001	105	view →
KIRC	DFS	Median	All	0.545	0.689	<.001	96	view →
STAD	OS	Median	All	0.669	0.489	<.001	66	view →
BRCA	DFS	Tertile	All	0.919	0.964	<.001	54	view →
UCS	OS	Quartile	II,III,IV	0.301	0.759	.002	50	view →
ACC	DFS	Median	All	0.344	0.747	.001	43	view →
UCEC	OS	Median	III,IV	0.449	0.725	.002	36	view →
KIRP	DFS	Median	IV	0.812	0.041	<.001	32	view →
LGG	OS	Quartile	All	0.546	0.330	<.001	29	view →
DLBC	DFS	Median	III,IV	0.482	0.923	.013	26	view →
ESCA	DFS	Median	All	0.271	0.430	.015	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0023041–BLCA (OS)

Open the BLCA breakdown →