Neuronal signal transduction

Across TCGA patient cohorts, RNA activity of the Neuronal signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GABRA2, MED30, and LEMD3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal signal transduction activity versus GABRA2 in GBM (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GABRA2 →	-0.808	-0.454	.001	<.001	3	3
GBM	MED30 →	-0.280	-0.535	.006	.001	3	3
GBM	LEMD3 →	-0.232	-0.402	.003	.002	3	3
PDAC	NEB →	+0.558	+0.581	.003	.004	3	3
HNSC	TMSB4XP3 →	-0.436	-0.629	.008	<.001	3	3
HNSC	COPRSP1 →	-0.424	-0.472	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023041 vs GABRA2 — GBM

Explore this scatter interactively →