Respiratory electron transport chain

Across TCGA patient cohorts, RNA activity of the Respiratory electron transport chain pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP13_S2498, IQGAP1, and KIF1A_S1370, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory electron transport chain activity versus AKAP13_S2498 in GBM (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AKAP13_S2498 →	-0.398	-0.032	<.001	<.001	3	6
GBM	IQGAP1 →	-0.412	-0.039	.001	.002	3	5
LSCC	KIF1A_S1370 →	+1.722	+0.036	.003	.004	2	6
HNSC	PRAG1 →	-0.212	-0.055	.003	.002	3	5
LSCC	PLIN3 →	-0.141	-0.030	.003	<.001	3	5
PDAC	LARP1_S689 →	+0.434	+0.030	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022904 vs AKAP13_S2498 — GBM

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