Electron transport chain

Across TCGA patient cohorts, RNA activity of the Electron transport chain pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, GRB10_S104, and SND1_S645, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Electron transport chain activity versus UCHL1 in LUAD (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UCHL1 →	+1.086	+0.028	<.001	<.001	3	5
LUAD	GRB10_S104 →	+0.694	+0.023	<.001	<.001	3	5
HNSC	SND1_S645 →	-0.632	-0.067	<.001	.004	3	5
GBM	EEF2 →	-0.264	-0.050	<.001	<.001	3	5
PDAC	SRSF3_S5 →	-0.370	-0.024	<.001	<.001	3	5
HNSC	KIF1A_S1370 →	+1.080	+0.042	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022900 vs UCHL1 — LUAD

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