Electron transport chain

Across TCGA cell cohorts, RNA activity of the Electron transport chain pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LLGL2, CLIP2, and SLC30A4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LLGL2 grouped by Electron transport chain-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LLGL2 →	+2.234	+0.289	<.001	<.001	3	5
LIVER	CLIP2 →	-1.346	-0.443	.006	<.001	3	4
LUNG_SCLC	SLC30A4 →	-0.923	-0.397	.008	.004	3	4
KIDNEY	PRAF2 →	-1.251	-0.277	<.001	<.001	3	4
BREAST	MB →	+2.092	+0.335	<.001	<.001	3	4
BREAST	ZC3H12C →	-0.962	-0.392	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LLGL2 by Electron transport chain activity — BREAST

Explore this box plot interactively →