Electron transport chain

Across TCGA cell cohorts, RNA activity of the Electron transport chain pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A17, NDRG2, and ETNK2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Electron transport chain activity versus SLC22A17 in OESOPHAGUS (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC22A17 →	+2.351	+0.099	<.001	<.001	3	14
OESOPHAGUS	NDRG2 →	+3.117	+0.157	<.001	<.001	3	14
SKIN	ETNK2 →	+1.349	+0.068	<.001	<.001	3	14
OVARY	EMID1 →	+1.445	+0.066	<.001	<.001	3	13
OESOPHAGUS	DUSP9 →	+1.843	+0.108	<.001	<.001	3	13
BONE	PCSK1N →	+2.988	+0.095	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022900 vs SLC22A17 — OESOPHAGUS

Explore this scatter interactively →