Electron transport chain

Across TCGA cell cohorts, RNA activity of the Electron transport chain pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP155, NCAPG, and CLSPN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Electron transport chain activity versus NUP155 in LARGE_INTESTINE (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUP155 →	-0.893	-0.287	<.001	.001	3	6
LIVER	NCAPG →	-1.144	-0.333	.003	.004	3	6
BLOOD_Leukemia	CLSPN →	-1.042	-0.216	<.001	.004	3	5
URINARY_TRACT	SYNE1 →	-1.645	-0.283	.007	.004	2	6
BLOOD_Leukemia	TENT4A →	-0.885	-0.297	<.001	<.001	3	5
LIVER	TACC3 →	-1.084	-0.433	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022900 vs NUP155 — LARGE_INTESTINE

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