Extracellular matrix disassembly

Across TCGA patient cohorts, RNA activity of the Extracellular matrix disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAU, MMP19, and MYO1F, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular matrix disassembly activity versus PLAU in BLCA (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PLAU →	+1.877	+0.046	<.001	<.001	3	28
UCS	MMP19 →	+1.674	+0.047	<.001	.005	2	29
SCLC	MYO1F →	+2.011	+0.175	<.001	<.001	3	28
SCLC	IL7R →	+2.314	+0.164	<.001	<.001	3	28
SCLC	GPR183 →	+1.803	+0.143	<.001	<.001	3	28
LAML	CD300LB →	+1.245	+0.042	.004	.003	2	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022617 vs PLAU — BLCA

Explore this scatter interactively →