Extracellular matrix disassembly

Across TCGA patient cohorts, RNA activity of the Extracellular matrix disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R18_S368, RCN3, and RSU1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular matrix disassembly activity versus PPP1R18_S368 in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R18_S368 →	+0.901	+0.117	<.001	<.001	3	10
LSCC	RCN3 →	+0.710	+0.086	<.001	<.001	3	9
BRCA	RSU1 →	+0.358	+0.042	<.001	<.001	3	9
OV	ASPN →	+1.234	+0.052	<.001	.001	3	9
OV	TAGLN →	+1.018	+0.049	<.001	<.001	3	9
UCEC	TBC1D2B →	+0.280	+0.069	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022617 vs PPP1R18_S368 — UCEC

Explore this scatter interactively →