Extracellular matrix disassembly

Across TCGA patient cohorts, RNA activity of the Extracellular matrix disassembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM12, VGLL3, and SPRED3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular matrix disassembly activity versus ADAM12 in OV (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ADAM12 →	+1.899	+0.245	<.001	<.001	3	9
OV	VGLL3 →	+1.255	+0.237	<.001	<.001	3	9
GBM	SPRED3 →	+0.564	+0.152	.005	.003	2	9
OV	MEIS3 →	+1.365	+0.260	<.001	<.001	3	8
COAD	SERPINE1 →	+1.695	+0.267	<.001	<.001	3	8
OV	DSE →	+0.551	+0.150	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022617 vs ADAM12 — OV

Explore this scatter interactively →