Extracellular matrix disassembly

Across TCGA patient cohorts, RNA activity of the Extracellular matrix disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAP, ANP32B, and P4HA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular matrix disassembly activity versus FAP in OV (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAP →	+1.423	+0.252	<.001	<.001	3	8
HNSC	ANP32B →	-0.337	-0.230	<.001	<.001	3	8
PDAC	P4HA2 →	+0.665	+0.155	<.001	<.001	3	8
OV	PLOD1 →	+0.785	+0.267	<.001	<.001	3	8
OV	CCDC80 →	+1.051	+0.249	<.001	<.001	2	8
OV	CD276 →	+0.482	+0.235	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022617 vs FAP — OV

Explore this scatter interactively →