Extracellular matrix disassembly

Across TCGA cell cohorts, RNA activity of the Extracellular matrix disassembly pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFRA4, RAB33A, and PRKCZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GFRA4 grouped by Extracellular matrix disassembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GFRA4 →	-0.280	-0.166	.002	.001	3	5
BREAST	RAB33A →	+0.162	+0.086	.003	.002	3	5
BREAST	PRKCZ →	-0.221	-0.095	.003	.003	3	4
BLOOD_Myeloma	FPR2 →	-0.404	-0.120	.001	.004	3	4
STOMACH	TNNI3K →	+0.178	+0.128	.003	.001	3	4
STOMACH	RUNX1 →	+0.243	+0.113	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GFRA4 by Extracellular matrix disassembly activity — STOMACH

Explore this box plot interactively →