Extracellular matrix disassembly

Across TCGA cell cohorts, RNA activity of the Extracellular matrix disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H2, C12orf73, and LAMC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular matrix disassembly activity versus P3H2 in LIVER (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	P3H2 →	+3.709	+0.398	.005	<.001	3	5
LUNG_SCLC	C12orf73 →	-0.371	-0.338	.001	.004	3	5
STOMACH	LAMC1 →	+2.440	+0.340	<.001	<.001	3	5
BLOOD_Leukemia	KLLN →	-0.505	-0.332	.004	.009	3	4
URINARY_TRACT	CBX2 →	-1.888	-0.498	.001	.002	3	4
BLOOD_Leukemia	TTC24 →	-1.823	-0.365	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022617 vs P3H2 — LIVER

Explore this scatter interactively →