DNA strand elongation

Across TCGA patient cohorts, RNA activity of the DNA strand elongation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and LIG1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA strand elongation activity versus SMC2 in UCEC (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC2 →	+0.679	+0.289	<.001	<.001	3	9
UCEC	SMC4 →	+0.577	+0.280	<.001	<.001	3	9
GBM	LIG1 →	+0.467	+0.311	<.001	<.001	3	9
UCEC	MAD2L1 →	+0.506	+0.251	<.001	<.001	3	9
BRCA	MCM2_S27 →	+0.729	+0.233	<.001	<.001	3	9
LSCC	MCM2_S41 →	+0.857	+0.393	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022616 vs SMC2 — UCEC

Explore this scatter interactively →