Protein to membrane docking

Across TCGA patient cohorts, RNA activity of the Protein to membrane docking pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC25A1, BCL2L13, and TRMT2A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein to membrane docking activity versus SLC25A1 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC25A1 →	+0.483	+0.031	.004	<.001	2	7
LUAD	BCL2L13 →	+0.272	+0.043	<.001	<.001	3	6
OV	TRMT2A →	+0.281	+0.039	.002	.001	3	6
CCRCC	MIEF1 →	+0.205	+0.052	<.001	<.001	3	6
OV	SNAP29 →	+0.429	+0.050	<.001	<.001	3	5
LSCC	COMT →	+0.429	+0.055	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022615 vs SLC25A1 — BRCA

Explore this scatter interactively →