Protein to membrane docking

Across TCGA patient cohorts, RNA activity of the Protein to membrane docking pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC15, NDUFB4P12, and SAPCD2P3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein to membrane docking activity versus LRRC15 in HNSC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LRRC15 →	+1.183	+0.178	.001	<.001	3	3
LUAD	NDUFB4P12 →	-0.322	-0.139	<.001	<.001	2	4
OV	SAPCD2P3 →	+0.076	+0.178	.001	<.001	3	3
CCRCC	H2BC18 →	-0.372	-0.086	.007	.003	3	3
BRCA	NSFL1C →	-0.348	-0.121	.001	.001	3	3
PDAC	COX5BP6 →	-0.542	-0.121	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022615 vs LRRC15 — HNSC

Explore this scatter interactively →