Protein to membrane docking

Across TCGA cell cohorts, RNA activity of the Protein to membrane docking pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOCAD, ARNTL, and LIN7A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOCAD grouped by Protein to membrane docking-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FOCAD →	-4.850	-2.273	.003	.001	3	3
BREAST	ARNTL →	-0.911	-0.803	.004	.009	3	3
SOFT_TISSUE	LIN7A →	-2.295	-1.127	<.001	.004	3	3
LUNG_SCLC	NRBP1 →	+0.811	+0.308	.001	.003	3	3
SOFT_TISSUE	CCDC114 →	+0.766	+1.102	<.001	.005	3	2
CNS	HSD17B1 →	+0.789	+1.972	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOCAD by Protein to membrane docking activity — CNS

Explore this box plot interactively →