Protein to membrane docking

Across TCGA cell cohorts, RNA activity of the Protein to membrane docking pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RWDD1, SNX3, and ZBTB24, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein to membrane docking activity versus RWDD1 in STOMACH (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RWDD1 →	+0.923	+0.191	.002	.001	2	9
STOMACH	SNX3 →	+0.923	+0.222	<.001	<.001	2	8
BONE	ZBTB24 →	+0.955	+0.418	.002	.004	3	6
BONE	THOP1 →	+0.947	+0.418	.003	.003	3	6
PANCREAS	PRMT9 →	+0.538	+0.179	<.001	.009	3	5
BREAST	RPF2 →	+0.803	+0.186	.006	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022615 vs RWDD1 — STOMACH

Explore this scatter interactively →