Membrane to membrane docking

Across TCGA patient cohorts, RNA activity of the Membrane to membrane docking pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD2, VSIG4, and PTAFR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane to membrane docking activity versus SOD2 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SOD2 →	+0.769	+0.245	<.001	<.001	3	4
GBM	VSIG4 →	+0.793	+0.532	.007	.005	3	4
GBM	PTAFR →	+0.718	+0.577	<.001	<.001	3	4
LSCC	RNASE6 →	+0.633	+0.442	.002	.002	3	4
GBM	LILRA5 →	+0.588	+0.593	.001	<.001	3	4
HNSC	FAS →	+1.044	+0.147	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022614 vs SOD2 — BRCA

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