Membrane to membrane docking

Across TCGA cell cohorts, RNA activity of the Membrane to membrane docking pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINB8, AXL, and ICAM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane to membrane docking activity versus SERPINB8 in LIVER (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SERPINB8 →	+2.875	+0.351	<.001	.002	3	8
SOFT_TISSUE	AXL →	+3.619	+0.395	.001	<.001	2	8
LUNG_NSCLC_LUAD	ICAM1 →	+2.460	+0.273	<.001	<.001	3	7
SKIN	SPTBN2 →	-2.071	-0.258	.001	.002	3	6
OESOPHAGUS	RAP1GAP →	-2.233	-0.216	.008	.007	2	7
SOFT_TISSUE	TICAM2 →	+1.846	+0.385	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022614 vs SERPINB8 — LIVER

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