Mammalian oogenesis stage

Across TCGA patient cohorts, RNA activity of the Mammalian oogenesis stage pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSCN1, VIM, and CERCAM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammalian oogenesis stage activity versus FSCN1 in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FSCN1 →	+0.511	+0.098	<.001	<.001	3	5
OV	VIM →	+0.358	+0.069	.005	<.001	3	4
OV	CERCAM →	+0.488	+0.064	.003	.004	3	4
HNSC	ERC1 →	+0.246	+0.067	.004	.008	3	4
HNSC	ACADSB →	-0.392	-0.063	<.001	.007	3	4
LSCC	SEC24D →	+0.298	+0.053	.002	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022605 vs FSCN1 — HNSC

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