Mammalian oogenesis stage

Across TCGA cell cohorts, RNA activity of the Mammalian oogenesis stage pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROX1, RHOB, and DAD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PROX1 grouped by Mammalian oogenesis stage-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PROX1 →	-0.236	-0.172	.009	<.001	3	5
OVARY	RHOB →	+0.190	+0.831	.003	.007	3	4
LIVER	DAD1 →	-0.273	-1.128	.007	.005	3	3
OESOPHAGUS	CHMP4B →	-0.167	-1.605	.001	<.001	3	3
BLOOD_Leukemia	MARCO →	-0.329	-0.117	.002	.001	3	3
OESOPHAGUS	RASSF7 →	-0.132	-1.201	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PROX1 by Mammalian oogenesis stage activity — BLOOD_Myeloma

Explore this box plot interactively →