Mammalian oogenesis stage

Across TCGA cell cohorts, RNA activity of the Mammalian oogenesis stage pathway is significantly associated with the total protein of multiple features, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are 14-3-3_beta, Gab2, and MEK1_p_S217_S221, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammalian oogenesis stage activity versus 14-3-3_beta in PANCREAS (Pearson r = -0.97).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	14-3-3_beta →	-0.271	-1.867	.021	.010	1	1
PANCREAS	Gab2 →	-1.605	-1.867	.006	.010	1	1
PANCREAS	MEK1_p_S217_S221 →	-0.544	-1.867	.036	.010	1	1
PANCREAS	p27_pT157 →	+0.125	+1.867	.012	.010	1	1
PANCREAS	p27 →	+0.216	+1.867	.007	.010	1	1
PANCREAS	PRDX1 →	+0.603	+1.867	.043	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022605 vs 14-3-3_beta — PANCREAS

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