Mammalian oogenesis stage

Across TCGA cell cohorts, RNA activity of the Mammalian oogenesis stage pathway is significantly associated with the drug response of multiple features, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are PD0325901, AZ20, and EphB4_9721, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PD0325901 grouped by Mammalian oogenesis stage-low versus -high activity in PANCREAS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PD0325901 →	+0.475	+1.867	.016	.010	1	1
PANCREAS	AZ20 →	-0.415	-1.867	.031	.010	1	1
PANCREAS	EphB4_9721 →	-0.575	-1.867	.028	.010	1	1
PANCREAS	Dacinostat →	+0.455	+1.867	.036	.010	1	1
PANCREAS	Idelalisib →	+0.644	+1.867	.042	.010	1	1
PANCREAS	Quizartinib →	-0.240	-1.867	.042	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PD0325901 by Mammalian oogenesis stage activity — PANCREAS

Explore this box plot interactively →