Ovulation cycle process

Across TCGA cell cohorts, RNA activity of the Ovulation cycle process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAUS3, ZNF280B, and GGCX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HAUS3 grouped by Ovulation cycle process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HAUS3 →	+0.834	+1.229	.002	.001	3	5
KIDNEY	ZNF280B →	+0.635	+1.224	.009	.001	3	4
BONE	GGCX →	+0.620	+1.956	.008	<.001	3	4
BONE	RFC1 →	+0.839	+1.795	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GDE1 →	+0.726	+1.111	.004	.005	3	4
BREAST	SMIM11A →	-0.904	-0.795	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HAUS3 by Ovulation cycle process activity — KIDNEY

Explore this box plot interactively →