Digestive system process

Across TCGA patient cohorts, RNA activity of the Digestive system process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC3, SRSF7, and SUPT6H, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Digestive system process activity versus RFC3 in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC3 →	-0.335	-0.066	<.001	<.001	3	8
GBM	SRSF7 →	-0.308	-0.074	<.001	<.001	3	8
LSCC	SUPT6H →	-0.316	-0.038	<.001	<.001	3	8
OV	VIRMA →	-0.192	-0.023	<.001	<.001	3	8
HNSC	BPTF →	-0.233	-0.038	<.001	.001	3	8
BRCA	CSE1L →	-0.363	-0.041	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022600 vs RFC3 — GBM

Explore this scatter interactively →