Digestive system process

Across TCGA patient cohorts, RNA activity of the Digestive system process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LIMA1_S15, AGR2, and BUD31, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Digestive system process activity versus LIMA1_S15 in BRCA (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LIMA1_S15 →	+0.930	+0.278	<.001	<.001	2	9
BRCA	AGR2 →	+0.928	+0.213	<.001	<.001	3	7
BRCA	BUD31 →	-0.316	-0.294	<.001	<.001	3	6
BRCA	AGR3 →	+0.871	+0.219	<.001	<.001	3	6
LSCC	SAFB →	-0.275	-0.201	<.001	<.001	3	5
LSCC	SMARCA5 →	-0.317	-0.178	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022600 vs LIMA1_S15 — BRCA

Explore this scatter interactively →