Membrane docking

Across TCGA cell cohorts, RNA activity of the Membrane docking pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD13B, SDC4, and ICAM1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane docking activity versus ANKRD13B in OVARY (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ANKRD13B →	-1.909	-0.280	<.001	<.001	3	11
OESOPHAGUS	SDC4 →	+2.800	+0.266	.001	<.001	3	9
STOMACH	ICAM1 →	+3.098	+0.255	.003	.005	3	9
LIVER	CTSD →	+1.478	+0.191	.001	.006	3	7
OVARY	KRT18 →	+2.957	+0.238	.003	.001	3	7
LUNG_NSCLC_LUAD	DAPP1 →	+1.601	+0.181	.006	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022406 vs ANKRD13B — OVARY

Explore this scatter interactively →