Metencephalon development

Across TCGA patient cohorts, RNA activity of the Metencephalon development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL39P16, ELOCP31, and C22orf31, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metencephalon development activity versus RPL39P16 in HNSC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL39P16 →	+0.895	+0.907	.004	<.001	3	4
HNSC	ELOCP31 →	+0.467	+0.700	.002	<.001	3	4
HNSC	C22orf31 →	+0.590	+0.605	<.001	.003	3	4
HNSC	WBP1 →	+0.399	+0.595	.009	.004	3	4
LSCC	SOX4 →	+0.860	+0.185	.003	.008	3	3
COAD	BOLA2P3 →	+0.273	+0.139	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022037 vs RPL39P16 — HNSC

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