Metencephalon development

Across TCGA cell cohorts, RNA activity of the Metencephalon development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBNDD1, NABP1, and ADRB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metencephalon development activity versus DBNDD1 in BONE (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DBNDD1 →	-2.436	-0.222	.009	.005	3	5
URINARY_TRACT	NABP1 →	+1.638	+0.246	.001	.002	3	4
OESOPHAGUS	ADRB2 →	-2.105	-0.281	.001	.002	3	3
OESOPHAGUS	CCDC121 →	+0.628	+0.279	.006	.001	3	3
OESOPHAGUS	AMIGO1 →	+1.099	+0.232	.007	.006	3	3
LIVER	SAC3D1 →	-0.760	-0.230	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022037 vs DBNDD1 — BONE

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