Telencephalon glial cell migration

Across TCGA patient cohorts, RNA activity of the Telencephalon glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYS1, NXPH3, and SCD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telencephalon glial cell migration activity versus CYS1 in HNSC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYS1 →	+0.603	+0.660	.001	.002	3	5
COAD	NXPH3 →	+0.515	+0.175	.002	.008	3	5
CCRCC	SCD5 →	+1.184	+0.472	<.001	<.001	3	5
CCRCC	OR7E13P →	+0.482	+0.554	.003	.001	3	5
LSCC	CRYAB →	+0.973	+0.189	.003	.003	3	5
CCRCC	SHROOM4 →	+0.570	+0.624	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022030 vs CYS1 — HNSC

Explore this scatter interactively →