Olfactory lobe development

Across TCGA cell cohorts, RNA activity of the Olfactory lobe development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM7, ELK1, and PLA2R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Olfactory lobe development activity versus MCM7 in SKIN (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MCM7 →	-0.768	-0.887	.006	.001	3	4
OVARY	ELK1 →	-0.831	-0.855	.001	.004	3	4
BLOOD_Leukemia	PLA2R1 →	+0.134	+0.872	.004	.004	3	4
OVARY	ZC3H7B →	-0.664	-0.988	.005	.007	3	3
OVARY	DAAM1 →	+1.665	+0.969	<.001	<.001	3	3
OVARY	RIOK3 →	+1.134	+1.371	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021988 vs MCM7 — SKIN

Explore this scatter interactively →