Hypothalamus cell differentiation

Across TCGA patient cohorts, RNA activity of the Hypothalamus cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBD, NRP1, and SEC11C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypothalamus cell differentiation activity versus THBD in LUAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	THBD →	+0.499	+0.577	.002	<.001	3	5
LUAD	NRP1 →	+0.541	+0.517	.002	.006	3	5
BRCA	SEC11C →	-0.710	-0.801	<.001	<.001	3	4
CCRCC	ERBB3 →	-0.933	-0.669	.002	<.001	3	4
OV	RNU6-446P →	+0.792	+0.130	<.001	<.001	3	4
LSCC	RN7SL510P →	+0.405	+0.717	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021979 vs THBD — LUAD

Explore this scatter interactively →