Anterior commissure morphogenesis

Across TCGA patient cohorts, RNA activity of the Anterior commissure morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, RFC4, and SMC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior commissure morphogenesis activity versus RFC1_S368 in COAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RFC1_S368 →	+0.471	+0.057	.001	<.001	3	5
LSCC	RFC4 →	+0.399	+0.100	<.001	<.001	3	5
PDAC	SMC2 →	+0.492	+0.073	<.001	<.001	3	5
COAD	CHAF1B_S410 →	+0.425	+0.046	.001	.002	3	5
LSCC	ABCF3 →	+0.235	+0.065	<.001	.001	2	6
CCRCC	EIF4G1 →	+0.204	+0.067	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021960 vs RFC1_S368 — COAD

Explore this scatter interactively →