Central nervous system neuron axonogenesis

Across TCGA cell cohorts, RNA activity of the Central nervous system neuron axonogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC74A, P2RX4, and BMPR1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRC74A grouped by Central nervous system neuron axonogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LRRC74A →	-0.323	-0.971	.001	.004	3	5
LUNG_SCLC	P2RX4 →	+0.181	+1.017	<.001	.003	3	4
BLOOD_Lymphoma	BMPR1A →	-0.576	-1.408	.006	<.001	3	4
BONE	CR2 →	+0.237	+1.337	.006	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	IRAK3 →	+0.130	+1.279	<.001	<.001	3	4
BONE	PCAT4 →	+0.290	+1.327	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRC74A by Central nervous system neuron axonogenesis activity — PANCREAS

Explore this box plot interactively →