Central nervous system neuron differentiation

Across TCGA patient cohorts, RNA activity of the Central nervous system neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL1A2, NRP1, and ESAM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system neuron differentiation activity versus COL1A2 in UCEC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COL1A2 →	+1.551	+0.455	.001	.001	3	4
UCEC	NRP1 →	+1.363	+0.412	.003	.004	3	4
OV	ESAM →	+0.790	+0.673	.008	.009	3	4
BRCA	SPARC →	+1.038	+0.789	<.001	<.001	3	4
CCRCC	AFAP1L1 →	+0.564	+0.531	<.001	.001	3	4
CCRCC	FBN1 →	+0.642	+0.652	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021953 vs COL1A2 — UCEC

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