Central nervous system neuron differentiation

Across TCGA cell cohorts, RNA activity of the Central nervous system neuron differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD5, UTS2R, and DSG3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FZD5 grouped by Central nervous system neuron differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FZD5 →	-0.142	-0.606	.006	.006	3	5
URINARY_TRACT	UTS2R →	-0.136	-0.220	.001	<.001	3	5
CNS	DSG3 →	+0.158	+0.394	<.001	.002	3	4
CNS	CCNG2 →	-0.206	-0.405	<.001	.001	3	4
BREAST	CTIF →	-0.356	-0.118	.005	.002	2	5
KIDNEY	WAS →	-0.159	-0.993	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FZD5 by Central nervous system neuron differentiation activity — OVARY

Explore this box plot interactively →