Hindbrain tangential cell migration

Across TCGA patient cohorts, RNA activity of the Hindbrain tangential cell migration pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHB2, NDEL1, and SCAF11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindbrain tangential cell migration activity versus EPHB2 in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EPHB2 →	+0.752	+0.447	.004	.002	3	5
COAD	NDEL1 →	-0.341	-0.619	.002	<.001	3	4
BRCA	SCAF11 →	-1.181	-0.409	<.001	<.001	3	4
BRCA	CXXC4 →	-1.921	-0.331	<.001	.002	3	3
COAD	MORC4 →	-0.679	-0.555	.003	.009	3	3
LSCC	GAST →	-1.704	-0.291	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021934 vs EPHB2 — HNSC

Explore this scatter interactively →