Hindbrain radial glia guided cell migration

Across TCGA cell cohorts, RNA activity of the Hindbrain radial glia guided cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDEM1, CEP112, and FADS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDEM1 grouped by Hindbrain radial glia guided cell migration-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EDEM1 →	-1.680	-0.614	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CEP112 →	-1.495	-2.029	<.001	<.001	3	4
BREAST	FADS1 →	-1.781	-0.779	.001	.002	3	4
LUNG_NSCLC_LUAD	BRCA1 →	-0.555	-0.690	.004	.006	3	3
LUNG_NSCLC_LUAD	TMEM67 →	-0.762	-0.832	.001	<.001	3	3
SKIN	BAG6 →	-0.403	-0.552	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDEM1 by Hindbrain radial glia guided cell migration activity — OESOPHAGUS

Explore this box plot interactively →