Neural tube development

Across TCGA cell cohorts, RNA activity of the Neural tube development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPARG, MTERF2, and BIK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural tube development activity versus PPARG in BONE (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PPARG →	+2.951	+0.328	.001	.007	3	6
PANCREAS	MTERF2 →	-0.775	-0.325	<.001	<.001	3	5
LUNG_NSCLC_LUAD	BIK →	+1.407	+0.250	.001	.001	3	5
STOMACH	SCML2 →	-2.007	-0.302	.005	.006	3	5
STOMACH	GTPBP3 →	-1.259	-0.296	.003	.006	3	5
STOMACH	ZNF101 →	-0.704	-0.285	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021915 vs PPARG — BONE

Explore this scatter interactively →