Smoothened signaling pathway involved in ventral spinal cord patterning
pathway activity — cross-omics
GO:0021910Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts
Across TCGA patient cohorts, RNA activity of the Smoothened signaling pathway involved in ventral spinal cord patterning pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.
The most reproducible pathway-associated genes across cancer lineages are PLXDC1, PDIA6, and SEMA5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.
Each partner is linked to its corresponding Q-omics profile.
Pathway-associated genes by consensus
Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.