Rostrocaudal neural tube patterning

Across TCGA cell cohorts, RNA activity of the Rostrocaudal neural tube patterning pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CGN, ENPP1, and INSIG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CGN grouped by Rostrocaudal neural tube patterning-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CGN →	+2.058	+0.550	.004	.008	3	4
BREAST	ENPP1 →	-1.758	-0.234	<.001	.002	3	3
OESOPHAGUS	INSIG1 →	-1.790	-0.146	.001	.003	3	3
SOFT_TISSUE	DAD1 →	-0.505	-0.269	<.001	.001	3	3
SOFT_TISSUE	AGTRAP →	-0.937	-0.370	.003	.002	3	3
SOFT_TISSUE	TRPV1 →	+0.473	+0.291	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CGN by Rostrocaudal neural tube patterning activity — CNS

Explore this box plot interactively →