Rostrocaudal neural tube patterning

Across TCGA pan-cancer cohorts, RNA activity of the Rostrocaudal neural tube patterning pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Rostrocaudal neural tube patterning pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD and UVM, show the opposite pattern, with higher activity associated with better survival.

COAD, UVM, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.758	0.517	.002	72	view →
UVM	OS	Median	All	0.745	0.420	<.001	72	view →
LIHC	OS	Tertile	II,III,IV	0.460	0.707	.001	55	view →
LUAD	OS	Quartile	II,III,IV	0.494	0.264	.006	34	view →
READ	OS	Tertile	III,IV	1.000	0.764	.009	26	view →
BLCA	DFS	Tertile	IV	0.489	0.275	.008	18	view →
SKCM	OS	Quartile	III,IV	0.787	0.278	.005	17	view →
DLBC	DFS	Quartile	II,III,IV	0.372	1.000	.006	7	view →
ACC	DFS	Median	All	0.610	0.314	.009	7	view →
TGCT	DFS	Tertile	II,III,IV	0.638	0.996	.037	6	view →
CHOL	OS	Median	III,IV	0.275	0.886	.045	6	view →
KICH	DFS	Median	II,III,IV	0.928	0.489	.021	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0021903–COAD (OS)

Open the COAD breakdown →