Cerebral cortex GABAergic interneuron development

Across TCGA patient cohorts, RNA activity of the Cerebral cortex GABAergic interneuron development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRMT5, FANCI, and MCM7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex GABAergic interneuron development activity versus TRMT5 in LSCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRMT5 →	+0.335	+0.350	<.001	<.001	3	7
LSCC	FANCI →	+0.526	+0.350	<.001	<.001	3	7
LSCC	MCM7 →	+0.481	+0.313	<.001	<.001	3	7
PDAC	VWA5A →	-0.278	-0.626	<.001	<.001	3	7
LSCC	RACGAP1 →	+0.427	+0.455	.005	.001	3	7
BRCA	ABI3BP →	-0.566	-0.103	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021894 vs TRMT5 — LSCC

Explore this scatter interactively →