Cerebral cortex GABAergic interneuron differentiation

Across TCGA patient cohorts, RNA activity of the Cerebral cortex GABAergic interneuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM7, TRMT5, and USP34, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex GABAergic interneuron differentiation activity versus MCM7 in COAD (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MCM7 →	+0.348	+0.108	.003	.001	3	6
PDAC	TRMT5 →	+0.211	+0.589	.001	<.001	3	5
COAD	USP34 →	+0.358	+0.083	.001	.005	3	5
HNSC	MCM2 →	+0.482	+0.581	<.001	.003	3	5
BRCA	ABI3BP →	-0.612	-0.102	.003	.003	2	6
HNSC	WDHD1_S868 →	+0.440	+0.639	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021892 vs MCM7 — COAD

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