Cerebral cortex GABAergic interneuron differentiation

Across TCGA cell cohorts, RNA activity of the Cerebral cortex GABAergic interneuron differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCN3B, WDR91, and RGSL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCN3B grouped by Cerebral cortex GABAergic interneuron differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SCN3B →	-0.238	-0.196	.009	.005	3	4
LUNG_SCLC	WDR91 →	+0.187	+1.688	.007	<.001	3	3
LUNG_SCLC	RGSL1 →	-0.159	-1.697	.003	<.001	3	3
LUNG_SCLC	LHX4 →	+0.221	+1.572	.005	<.001	3	3
LUNG_SCLC	CXCL6 →	+0.187	+1.105	.001	.009	3	3
KIDNEY	POGZ →	+0.239	+0.141	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCN3B by Cerebral cortex GABAergic interneuron differentiation activity — URINARY_TRACT

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