Olfactory bulb interneuron differentiation

Across TCGA patient cohorts, RNA activity of the Olfactory bulb interneuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GOLIM4, SEMA6A_S715, and SLIT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Olfactory bulb interneuron differentiation activity versus GOLIM4 in UCEC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GOLIM4 →	+0.429	+0.083	.002	<.001	3	6
LSCC	SEMA6A_S715 →	+1.158	+0.142	<.001	<.001	3	4
BRCA	SLIT2 →	+0.430	+0.066	<.001	.002	3	4
BRCA	SRPK1_S311 →	-0.439	-0.041	.008	.006	3	4
BRCA	CD248 →	+0.349	+0.049	.001	.008	2	5
LUAD	FASTKD5 →	-0.341	-0.080	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021889 vs GOLIM4 — UCEC

Explore this scatter interactively →