Hypothalamus gonadotrophin-releasing hormone neuron differentiation

Across TCGA patient cohorts, RNA activity of the Hypothalamus gonadotrophin-releasing hormone neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NRP2, SEC23A, and TUBB6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypothalamus gonadotrophin-releasing hormone neuron differentiation activity versus NRP2 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NRP2 →	+0.519	+0.117	<.001	<.001	3	8
OV	SEC23A →	+0.312	+0.084	.001	.005	3	7
OV	TUBB6 →	+0.427	+0.098	.001	.001	3	7
UCEC	VIM →	+0.519	+0.096	<.001	<.001	3	7
PDAC	P4HA2 →	+0.594	+0.058	<.001	<.001	2	8
GBM	PLOD1 →	+0.513	+0.090	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021886 vs NRP2 — LSCC

Explore this scatter interactively →